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Table 1 Combined disruption of Dido and Ku80 is embryonic lethal.

From: Merotelic attachments and non-homologous end joining are the basis of chromosomal instability

Ku80 Dido N° pups (expected) N° pups (observed)
+/+ +/+ 78.75 147
+/+ +/neo 157.50 278
+/+ neo/neo 78.75 49
+/- +/+ 157.50 216
+/- +/neo 315.00 411
+/- neo/neo 157.50 88
-/- +/+ 78.75 24
-/- +/neo 157.50 47
-/- neo/neo 78.75 0
Total 1260 1260
  1. Mice heterozygous for Dido and Ku80 were crossed and all viable pups were genotyped. Ku80-/- and Didoneo/neo pups were born at a lower frequency than heterozygous littermates. No double mutant mice were born in a population of >1000 animals.
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Cell Division

ISSN: 1747-1028

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